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He said he could not help and apologised because he was not sure who it was. Despite the apology, when he came home his wife was.
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Follow Carl. “I couldn't get her to sign the forms, so I took her to the hospital. At the.Major depressive disorder (MDD) is the leading cause of disability worldwide, with severe functional impairment and a very high likelihood of chronicity. Approximately 30% of patients fail to recover despite the usual treatment strategies.
In the current issue of *Neuropsychopharmacology*, Zhu et al. ([@CIT0001]) report a single-blind, randomized, placebo-controlled, three-arm trial investigating the efficacy and safety of two doses of bupropion in patients with MDD who had previously responded inadequately to an antidepressant regimen, either alone or in combination with serotonin- noradrenaline reuptake inhibitors. This study demonstrated that bupropion at doses up to 300 mg/day was well tolerated in patients with MDD, and was efficacious for the acute treatment of these patients.
Bupropion is one of three antidepressants, along with escitalopram and venlafaxine, that have a mechanism of action involving inhibition of the reuptake of the neurotransmitter norepinephrine (NE) and the trace amine-associated receptor 1 (TAAR1). The efficacy of bupropion in the treatment of MDD has been demonstrated in placebo-controlled trials in which bupropion demonstrated faster onset of action compared to SSRIs ([@CIT0002]). The bupropion metabolite norbuprenorphine also inhibits TAAR1, albeit with a lower potency compared to bupropion. A large be359ba680
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